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References

Vitamin B12 Deficiency - Causes, Symptoms, Treatment

  1. Prof. Dr. med. habil. Dr. rer. nat. Wolfgang Herrmann, , Dr. rer. med. Rima Obeid: Review Article, Causes and Early Diagnosis of Vitamin B12 Deficiency; Dtsch Arztebl Int. 2008 Oct; 105(40): 680–685.; Published online 2008 Oct 3. doi: 10.3238/arztebl.2008.0680; PMCID: PMC2696961
  2. Lindsay H Allen: How common is vitamin B-12 deficiency?; First published December 30, 2008, doi: 10.3945/ajcn.2008.26947A; Am J Clin Nutr February 2009; vol. 89 no. 2 693S-696S
  3. Stabler SP, Allen RH.: Vitamin B12 deficiency as a worldwide problem.; Annu Rev Nutr. 2004;24:299-326.; PMID: 15189123
  4. Belghith A, Mahjoub S, Ben Romdhane N.: Causes of vitamin B12 deficiency.; Tunis Med. 2015 Nov;93(11):678-82.; PMID: 27126423
  5. Herrmann W, Schorr H, Obeid R, Geisel J.: Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians.; Am J Clin Nutr. 2003 Jul;78(1):131-6.; PMID: 12816782
  6. Gilsing AM, Crowe FL, Lloyd-Wright Z, Sanders TA, Appleby PN, Allen NE, Key TJ.: Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians and vegans: results from a cross-sectional analysis of the EPIC-Oxford cohort study.; Eur J Clin Nutr. 2010 Sep;64(9):933-9. doi: 10.1038/ejcn.2010.142. Epub 2010 Jul 21.; PMID: 20648045
  7. Philip J Tuso, MD; Mohamed H Ismail, MD; Benjamin P Ha, MD; Carole Bartolotto, MA, RD: Nutritional Update for Physicians: Plant-Based Diets; Perm J. 2013 Spring; 17(2): 61–66.; doi: 10.7812/TPP/12-085; PMCID: PMC3662288
  8. Hokin BD, Butler T.: Cyanocobalamin (vitamin B-12) status in Seventh-day Adventist ministers in Australia.; Am J Clin Nutr. 1999 Sep;70(3 Suppl):576S-578S.; PMID: 10479234
  9. Majchrzak D, Singer I, Männer M, Rust P, Genser D, Wagner KH, Elmadfa I.: B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians, and vegans.; Ann Nutr Metab. 2006;50(6):485-91. Epub 2006 Sep 19.; PMID: 16988496
  10. Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucas D.: How prevalent is vitamin B(12) deficiency among vegetarians?; Nutr Rev. 2013 Feb;71(2):110-7. doi: 10.1111/nure.12001. Epub 2013 Jan 2.; PMID: 23356638
  11. Nadja B. Kristensen, Mia L. Madsen, Tue H. Hansen, Kristine H. Allin, Camilla Hoppe, Sisse Fagt, Mia S. Lausten, Rikke J. Gøbel, Henrik Vestergaard, Torben Hansen, and Oluf Pedersen: Intake of macro- and micronutrients in Danish vegans; Nutr J. 2015; 14: 115.; Published online 2015 Oct 30. doi: 10.1186/s12937-015-0103-3; PMCID: PMC4628270
  12. Jakub G. Sobiecki, Paul N. Appleby, Kathryn E. Bradbury, Timothy J. Key: High compliance with dietary recommendations in a cohort of meat eaters, fish eaters, vegetarians, and vegans: results from the European Prospective Investigation into Cancer and Nutrition–Oxford study; Nutr Res. 2016 May;36 (5):464-77.; DOI: 10.1016/j.nutres.2015.12.016
  13. Ambroszkiewicz J, Klemarczyk W, Chełchowska M, Gajewska J, Laskowska-Klita T.: Serum homocysteine, folate, vitamin B12 and total antioxidant status in vegetarian children.; Adv Med Sci. 2006;51:265-8.; PMID: 17357323
  14. Lücke T, Korenke GC, Poggenburg I, Bentele KH, Das AM, Hartmann H.: Maternal vitamin B12 deficiency: cause for neurological symptoms in infancy.; Z Geburtshilfe Neonatol. 2007 Aug;211(4):157-61.; PMID: 17729202
  15. Sanwar Agrawal, Shweta Nathani: Neuro-regression in vitamin B12 deficiency; BMJ Case Rep. 2009; 2009: bcr06.2008.0235. Published online 2009 Mar 17.; doi: 10.1136/bcr.06.2008.0235; PMCID: PMC3029636
  16. Pawlak R, Lester SE, Babatunde T.: The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature.; Eur J Clin Nutr. 2014 May;68(5):541-8.; doi: 10.1038/ejcn.2014.46. Epub 2014 Mar 26.; PMID: 24667752
  17. ROBERT C. LANGAN, MD, and KIMBERLY J. ZAWISTOSKI, DO: Update on Vitamin B12 Deficiency; Am Fam Physician. 2011 Jun 15;83(12):1425-1430.; Jun 15, 2011 Issue
  18. Carmel R.: Malabsorption of food cobalamin.; Baillieres Clin Haematol. 1995 Sep;8(3):639-55.; PMID: 8534965
  19. Andrès E, Perrin AE, Demangeat C, Kurtz JE, Vinzio S, Grunenberger F, Goichot B, Schlienger JL.: The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients.; Eur J Intern Med. 2003 Jul;14(4):221-226.; PMID: 12919836
  20. The President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health > The Nutrition Source > Vitamin B12 Deficiency: Causes and Symptoms: Vitamin B12 Deficiency: Causes and Symptoms; accessed on 07/12/2015
  21. Pontes HA, Neto NC, Ferreira KB, Fonseca FP, Vallinoto GM, Pontes FS, Pinto Ddos S Jr.: Oral manifestations of vitamin B12 deficiency: a case report.; J Can Dent Assoc. 2009 Sep;75(7):533-7.; PMID: 19744365
  22. WebMD, LLC: Vitamin B12 Deficiency; accessed on 12/07/2015
  23. Biyani S, Jha SK, Pandey S, Shukla R.: Acute bilateral useless hand syndrome: a rare presenting manifestation of vitamin B12 deficiency.; BMJ Case Rep. 2015 Oct 16;2015. pii: bcr2015210067. doi: 10.1136/bcr-2015-210067.; PMID: 26475874
  24. C. Vera-Kellet, R. Andino-Navarrete, L. Navajas-Galimany: Vitamin B12 Deficiency and its Numerous Skin Manifestations; Actas Dermosifiliogr. 2015;106:762-4 - Vol. 106 Num.9 DOI: 10.1016/j.adengl.2015.09.017
  25. W. Y. Tham, C. C. Oh, H. Y. Koh: Pernicious anaemia presenting as hyperpigmentation; Clinical and Experimental Dermatology Volume 40, Issue 6, pages 626–628, August 2015; Article first published online: 18 MAR 2015; DOI: 10.1111/ced.12600
  26. Brescoll J, Daveluy S.: A review of vitamin B12 in dermatology.; Am J Clin Dermatol. 2015 Feb;16(1):27-33. doi: 10.1007/s40257-014-0107-3.; PMID: 25559140
  27. Carol L Zeuschner, Bevan D Hokin, Kate A Marsh, Angela V Saunders, Michelle A Reid, Melinda R Ramsay: Vitamin B12 and vegetarian diets; Med J Aust 2013; 199 (4 Suppl): S27-S32.; doi: 10.5694/mja11.11509; accessed on 07/12/2015
  28. U.S. National Library of Medicine: Anemia - B12 deficiency; accessed on 07/12/2015
  29. Winston J Craig: Health effects of vegan diets; First published March 11, 2009, doi: 10.3945/ajcn.2009.26736N; Am J Clin Nutr May 2009; vol. 89 no. 5 1627S-1633S
  30. Lang U.E., Beglinger C., Schweinfurth N., Walter M., Borgwardt S.: Nutritional Aspects of Depression; Cell Physiol Biochem 2015;37:1029-1043; DOI:10.1159/000430229
  31. Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D.: Cognitive impairment and vitamin B12: a review.; Int Psychogeriatr. 2012 Apr;24(4):541-56. doi: 10.1017/S1041610211002511. Epub 2012 Jan 6.; PMID: 22221769
  32. Miles LM, Mills K, Clarke R, Dangour AD.: Is there an association of vitamin B12 status with neurological function in older people? A systematic review.; Br J Nutr. 2015 Aug 28;114(4):503-8. doi: 10.1017/S0007114515002226. Epub 2015 Jul 23.; PMID: 26202329
  33. ROBERT C. OH, CPT, MC; DAVID L. BROWN, MAJ, MC: Vitamin B12 Deficiency; Am Fam Physician. 2003 Mar 1;67(5):979-986.; Mar 1, 2003 Issue
  34. Førland ES, Lindberg MJ.: Severe macrocytic anemia and secondary hyperparathyroidism in a vegan.; Ugeskr Laeger. 2015 Aug 10;177(33):V02150167.; PMID: 26320356
  35. University of Rochester Medical Center: Anemia of B12 Deficiency; accessed on 12/07/2015
  36. Michael J Shipton, Jecko Thachil: Vitamin B12 deficiency – A 21st-century perspective; doi: 10.7861/clinmedicine.15-2-145; Clin Med April 1, 2015 vol. 15 no. 2 145-150
  37. Mithal A, Bonjour JP, Boonen S, Burckhardt P, Degens H, El Hajj Fuleihan G, Josse R, Lips P, Morales Torres J, Rizzoli R, Yoshimura N, Wahl DA, Cooper C, Dawson-Hughes B; IOF CSA Nutrition Working Group.: Impact of nutrition on muscle mass, strength, and performance in older adults.; Osteoporos Int. 2013 May;24(5):1555-66. doi: 10.1007/s00198-012-2236-y. Epub 2012 Dec 18.; PMID: 23247327
  38. Lukaski HC.: Vitamin and mineral status: effects on physical performance.; Nutrition. 2004 Jul-Aug;20(7-8):632-44.; PMID: 15212745
  39. Pawlak R.: Is vitamin B12 deficiency a risk factor for cardiovascular disease in vegetarians?; Am J Prev Med. 2015 Jun;48(6):e11-26. doi: 10.1016/j.amepre.2015.02.009.; PMID: 25998928
  40. Chen H, Liu S, Ji L, Wu T, Ma F, Ji Y, Zhou Y, Zheng M, Zhang M, Huang G.: Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study.; Curr Alzheimer Res. 2015;12(1):88-94.; PMID: 25523421
  41. Shen L, Ji HF.: Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses.; J Alzheimers Dis. 2015 Jun 25;46(3):777-90. doi: 10.3233/JAD-150140.; PMID: 25854931
  42. Pepper MR, Black MM.: B12 in fetal development.; Semin Cell Dev Biol. 2011 Aug;22(6):619-23. doi: 10.1016/j.semcdb.2011.05.005. Epub 2011 Jun 6.; PMID: 21664980
  43. Maureen M. Black: Effects of vitamin B12 and folate deficiency on brain development in children; Food Nutr Bull. Author manuscript; available in PMC 2011 Jul 18.; Published in final edited form as: Food Nutr Bull. 2008 Jun; 29(2 Suppl): S126–S131.; PMCID: PMC3137939; NIHMSID: NIHMS307261
  44. Strand TA, Taneja S, Kumar T, Manger MS, Refsum H, Yajnik CS, Bhandari N.: Vitamin B-12, folic acid, and growth in 6- to 30-month-old children: a randomized controlled trial.; Pediatrics. 2015 Apr;135(4):e918-26. doi: 10.1542/peds.2014-1848.; PMID: 25802345
  45. Roed C, Skovby F, Lund AM.: Severe vitamin B12 deficiency in infants breastfed by vegans.; Ugeskr Laeger. 2009 Oct 19;171(43):3099-101.; PMID: 19852900
  46. Chalouhi C, Faesch S, Anthoine-Milhomme MC, Fulla Y, Dulac O, Chéron G.: Neurological consequences of vitamin B12 deficiency and its treatment.; Pediatr Emerg Care. 2008 Aug;24(8):538-41. doi: 10.1097/PEC.0b013e318180ff32.; PMID: 18708898
  47. Lücke T, Korenke GC, Poggenburg I, Bentele KH, Das AM, Hartmann H.: Maternal vitamin B12 deficiency: cause for neurological symptoms in infancy.; Z Geburtshilfe Neonatol. 2007 Aug;211(4):157-61.; PMID: 17729202
  48. Zekai Avci, Tuba Turul, Sabiha Aysun, Işıil Ünal: Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency; Pediatrics September 2003, VOLUME 112 / ISSUE 3
  49. Kühne T, Bubl R, Baumgartner R.: Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency.; Eur J Pediatr. 1991 Jan;150(3):205-8.; PMID: 2044594
  50. Wagnon J, Cagnard B, Bridoux-Henno L, Tourtelier Y, Grall JY, Dabadie A.: Breastfeeding and vegan diet.; J Gynecol Obstet Biol Reprod (Paris). 2005 Oct;34(6):610-2.; PMID: 16208206
  51. Lücke T, Korenke GC, Poggenburg I, Bentele KH, Das AM, Hartmann H.: Maternal vitamin B12 deficiency: cause for neurological symptoms in infancy.; Z Geburtshilfe Neonatol. 2007 Aug;211(4):157-61.; PMID: 17729202
  52. Zekai Avci, Tuba Turul, Sabiha Aysun, Işıil Ünal: Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency; Pediatrics September 2003, VOLUME 112 / ISSUE 3
  53. Yilmaz S, Serdaroglu G, Tekgul H, Gokben S.: Different Neurologic Aspects of Nutritional B12 Deficiency in Infancy.; J Child Neurol. 2015 Aug 26. pii: 0883073815601497.; PMID: 26310585
  54. Chalouhi C, Faesch S, Anthoine-Milhomme MC, Fulla Y, Dulac O, Chéron G.: Neurological consequences of vitamin B12 deficiency and its treatment.; Pediatr Emerg Care. 2008 Aug;24(8):538-41. doi: 10.1097/PEC.0b013e318180ff32.; PMID: 18708898
  55. Roed C, Skovby F, Lund AM.: Severe vitamin B12 deficiency in infants breastfed by vegans.; Ugeskr Laeger. 2009 Oct 19;171(43):3099-101.; PMID: 19852900
  56. Sanwar Agrawal, Shweta Nathani: Neuro-regression in vitamin B12 deficiency; BMJ Case Rep. 2009; 2009: bcr06.2008.0235. Published online 2009 Mar 17.; doi: 10.1136/bcr.06.2008.0235; PMCID: PMC3029636
  57. ROBERT C. OH, CPT, MC; DAVID L. BROWN, MAJ, MC: Vitamin B12 Deficiency; Am Fam Physician. 2003 Mar 1;67(5):979-986.
  58. Larry E. Johnson, MD, PhD: Vitamin B 12 (Cobalamins); accessed on 07.12.2015
  59. Prof. Dr. med. habil. Dr. rer. nat. Wolfgang Herrmann, , Dr. rer. med. Rima Obeid: Review Article, Causes and Early Diagnosis of Vitamin B12 Deficiency; Dtsch Arztebl Int. 2008 Oct; 105(40): 680–685.; Published online 2008 Oct 3. doi: 10.3238/arztebl.2008.0680; PMCID: PMC2696961
  60. Schwarz J, Morstadt E, Dura A, Wintgens KF, Hartmann K, Armbruster FP, Dschietzig T.: Biochemical Identification of Vitamin B12 Deficiency in a Medical Office.; Clin Lab. 2015;61(7):687-92.; PMID: 26299066
  61. Michael J Shipton, Jecko Thachil: Vitamin B12 deficiency – A 21st-century perspective; doi: 10.7861/clinmedicine.15-2-145; Clin Med April 1, 2015, vol. 15, no. 2, 145-150
  62. Wolfgang Herrmann, Heike Schorr, Rima Obeid, Jürgen Geisel: Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians; Am J Clin Nutr July 2003; vol. 78, no. 1, 131-136
  63. ROBERT C. LANGAN, MD, and KIMBERLY J. ZAWISTOSKI, DO: Update on Vitamin B12 Deficiency; Am Fam Physician. 2011 Jun 15;83(12):1425-1430.; Jun 15, 2011 Issue
  64. ROBERT C. LANGAN, MD, and KIMBERLY J. ZAWISTOSKI, DO: Update on Vitamin B12 Deficiency; Am Fam Physician. 2011 Jun 15;83(12):1425-1430.; Jun 15, 2011 Issue
  65. U.S. National Library of Medicine: Vitamin B12; accessed on 12/07/2015
  66. Solmaz S, Özdoğu H, Boğa C.: Cobalamin deficiency can mask depleted body iron reserves.; Indian J Hematol Blood Transfus. 2015 Jun;31(2):255-8. doi: 10.1007/s12288-014-0417-x. Epub 2014 Jun 14.; PMID: 25825568
  67. Amir Sharabi, Eytan Cohen, Jaqueline Sulkes, Moshe Garty: Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route; Br J Clin Pharmacol. 2003 Dec; 56(6): 635–638.; doi: 10.1046/j.1365-2125.2003.01907.x; PMCID: PMC1884303
  68. Yazaki Y, Chow G, Mattie M.: A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels.; J Altern Complement Med. 2006 Nov;12(9):881-5.; PMID: 17109579
  69. Sharabi A, Cohen E, Sulkes J, Garty M.: Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route.; Br J Clin Pharmacol. 2003 Dec;56(6):635-8.; PMID: 14616423
  70. Chiara Briani, Chiara Dalla Torre, Valentina Citton, Renzo Manara, Sara Pompanin, Gianni Binotto, Fausto Adami: Cobalamin Deficiency: Clinical Picture and Radiological Findings; Nutrients. 2013 Nov; 5(11): 4521–4539.; Published online 2013 Nov 15. doi: 10.3390/nu5114521; PMCID: PMC3847746
  71. K Thakkar, G Billa: Treatment of vitamin B12 deficiency–Methylcobalamin? Cyancobalamin? Hydroxocobalamin?—clearing the confusion; European Journal of Clinical Nutrition (2015) 69, 1–2; doi:10.1038/ejcn.2014.165; published online 13 August 2014
  72. Ralph Carmel: How I treat cobalamin (vitamin B12) deficiency; Blood. 2008 Sep 15; 112(6): 2214–2221.; Prepublished online 2008 Jul 7. doi: 10.1182/blood-2008-03-040253; PMCID: PMC2532799
  73. ROBERT C. LANGAN, MD, and KIMBERLY J. ZAWISTOSKI, DO: Update on Vitamin B12 Deficiency; Am Fam Physician. 2011 Jun 15;83(12):1425-1430.; Jun 15, 2011 Issue
  74. Duyvendak M, Veldhuis GJ.: Oral better than parenteral supplementation of vitamin B12.; Ned Tijdschr Geneeskd. 2009;153:B485.; PMID: 19900336
  75. Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A.: Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency.; Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004655.; PMID: 16034940
  76. Michael R. Kolber, MD MSc CCFP, Sherilyn K.D. Houle, RPh PhD: Oral vitamin B12: a cost-effective alternative; Can Fam Physician. 2014 Feb; 60(2): 111–112.; PMCID: PMC3922551
  77. Ralph Carmel: How I treat cobalamin (vitamin B12) deficiency; Blood. 2008 Sep 15; 112(6): 2214–2221.; Prepublished online 2008 Jul 7. doi: 10.1182/blood-2008-03-040253; PMCID: PMC2532799
  78. Katherine L Tucker, Sharron Rich, Irwin Rosenberg, Paul Jacques, Gerard Dallal, Peter WF Wilson, Jacob Selhub: Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study; Am J Clin Nutr February 2000; vol. 71 no. 2 514-522
  79. Schüpbach R, Wegmüller R, Berguerand C, Bui M, Herter-Aeberli I.: Micronutrient status and intake in omnivores, vegetarians and vegans in Switzerland.; Eur J Nutr. 2015 Oct 26.; PMID: 26502280
  80. Patrick J. Skerrett: Vitamin B12 deficiency can be sneaky, harmful; Harvard Health Blog; accessed on 12/07/2015
  81. Kam S. Woo, Timothy C.Y. Kwok, David S. Celermajer: Vegan Diet, Subnormal Vitamin B-12 Status and Cardiovascular Health; Nutrients. 2014 Aug; 6(8): 3259–3273.; Published online 2014 Aug 19. doi: 10.3390/nu6083259; PMCID: PMC4145307